Senolytic supplements work by disrupting the survival pathways of senescent cells, which are cells that have stopped dividing and contribute to aging and various diseases. These supplements target and eliminate these harmful cells, leading to improved health and longevity. 

Let us delve into the five ways how senolytic supplements disrupt the survival pathways of senescent cells.

Inhibiting anti-apoptotic proteins

Senescent cells produce anti-apoptotic proteins that help them avoid programmed cell death. Senolytic supplements inhibit these proteins, making it easier for the body to eliminate these dysfunctional cells. This helps clear out old cells and make way for new, healthy ones.

Targeting specific signaling pathways

Senescent cells rely on specific signaling pathways for survival. Senolytic supplements disrupt these pathways, such as the PI3K/AKT or BCL-2 pathways, which are crucial for cell survival. Blocking these signals triggers the death of senescent cells.

Reducing cellular resistance

Senescent cells often develop resistance to cell death. Senolytic supplements reduce this resistance by targeting and weakening the cell’s defense mechanisms. This makes it easier for the immune system to identify and remove these cells.

Enhancing immune surveillance

Senolytic supplements improve the immune system’s ability to recognize and destroy senescent cells. By boosting immune surveillance, these supplements help maintain a healthier cellular environment, reducing the accumulation of harmful cells.

Promoting autophagy

Autophagy is the body’s process of cleaning out damaged cells. Senolytic supplements promote autophagy, encouraging the removal of senescent cells. This process helps rejuvenate tissues and supports overall cellular health.

The conclusion 

Senolytic supplements offer a promising approach to healthy aging by disrupting the survival pathways of senescent cells. By inhibiting anti-apoptotic proteins, targeting specific signaling pathways, reducing cellular resistance, enhancing immune surveillance, and promoting autophagy, these supplements can significantly improve health and longevity. Integrating senolytic supplements into your wellness routine can pave the way for a healthier, more vibrant life. Understanding their mechanism helps appreciate the potential benefits they offer.